The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Microorganisms engage in complex interactions with other organisms and their
environment. Recent studies have shown that these interactions are not limited to the …

The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …

Engineering the synthesis of massive amounts of therapeutics, enzymes or commodity
chemicals can select for subpopulations of nonproducer cells, owing to metabolic burden …

Over the past thirty years, since the dawn of metagenomic studies, a completely new (micro)
universe was revealed, with the potential to have profound impacts on many aspects of the …

Highlights•Industrially produced B vitamins are widely used in feed, food, cosmetics and
pharma.•Most B vitamins are produced by chemical synthesis in a non-sustainable …

Highlights•Recent technological advances amplify the power of yeast evolutionary
engineering.•Dynamic selection regimes can mitigate phenotypic trade-off …

Adaptive laboratory evolution (ALE) has served as a historic microbial engineering method
that mimics natural selection to obtain desired microbes. The past decade has witnessed …

Engineering microbial cells to efficiently synthesize high-value-added natural products has
received increasing attention in recent years. In this review, we describe the pipeline to build …

Transcription factor-based biosensors are used to identify producer strains, a critical
bottleneck in cell factory engineering. Here, we address two challenges with this …