Significance: Social and demographic changes have led to an increased prevalence of
loneliness and social isolation in modern society. Recent Advances: Population-based …

The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

Loneliness and social isolation are common sources of chronic stress in modern society.
Epidemiological studies have demonstrated that loneliness and social isolation increase …

Many experimental approaches require housing rodents in individual cages, including in
epilepsy research. However, rats and mice are social animals; and individual housing …

The response of the human body to multiple spaceflight stressors is complex, but mounting
evidence implicate risks to CNS functionality as significant, able to threaten metrics of …

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and
its incidence is expected to increase. Despite tremendous efforts to understand its …

Various stressors may disrupt the redox homeostasis of an organism by causing oxidative
and nitrosative stress that may activate stressor-specific pathways and provoke specific …

Animal models are useful preclinical tools for studying the pathogenesis of mental disorders
and the effectiveness of their treatment. While it is not possible to mimic all symptoms …

We assessed the antidepressant-like effects of environmental enrichment (EE) and physical
exercise (PE) compared with the selective serotonin reuptake inhibitor fluoxetine against the …

Prior research suggests that the neurobiological underpinnings of depression include
aberrant brain functional connectivity, neurometabolite levels, and hippocampal volume …