Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could
revolutionize both basic and clinical neuroscience. Toward this goal, we have developed …

Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic factor (BDNF) in
the pathophysiology of epilepsy. Aim of our work is to report the most important findings …

Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

Epilepsy is one of the most common neurological disorders. Although many factors
contribute to epileptogenesis, seizure generation is mostly linked to hyperexcitability due to …

Neonatal period is the most vulnerable time for the occurrence of seizures, and neonatal
seizures often pose a clinical challenge both for their acute management and frequency of …

Neonatal seizures are a common neurologic emergency for which therapies have not
significantly changed in decades. Improvements in diagnosis and pathophysiologic …

Neonatal seizures have an incidence of 3.5 per 1000 newborns; while hypoxic-ischemic
encephalopathy (HIE) accounts for 50–60% of cases, half are resistant to 1st-line anti …

Neonatal seizures pose a clinical challenge in their early detection, acute management, and
long-term comorbidities. They are often caused by hypoxic-ischemic encephalopathy and …