Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation
V Sorokin, K Vickneson, T Kofidis, CC Woo… - Frontiers in …, 2020 - frontiersin.org
The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …
approaches to address its high morbidity and mortality. To date, over 17 million …
The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation: involvement of vitamin K-dependent processes
P Petsophonsakul, M Furmanik, R Forsythe… - … , and vascular biology, 2019 - Am Heart Assoc
Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …
Endothelial cell dysfunction and increased cardiovascular risk in patients with chronic kidney disease
CC Baaten, S Vondenhoff, H Noels - Circulation research, 2023 - Am Heart Assoc
The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …
Endothelial–vascular smooth muscle cells interactions in atherosclerosis
M Li, M Qian, K Kyler, J Xu - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Atherosclerosis is a chronic progressive inflammatory process that can eventually lead to
cardiovascular disease (CVD). Despite available treatment, the prevalence of …
cardiovascular disease (CVD). Despite available treatment, the prevalence of …
Endoplasmic reticulum stress mediates vascular smooth muscle cell calcification via increased release of Grp78 (glucose-regulated protein, 78 kDa)-loaded …
M Furmanik, R van Gorp, M Whitehead… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Vascular calcification is common among aging populations and mediated by
vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in …
vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in …
Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm …
X Liu, W Chen, G Zhu, H Yang, W Li, M Luo, C Shu… - Cell discovery, 2022 - nature.com
Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition characterized
by medial layer degeneration of the thoracic aorta. A thorough understanding of the …
by medial layer degeneration of the thoracic aorta. A thorough understanding of the …
Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
The role of biomechanical stress in extracellular vesicle formation, composition and activity
W Thompson, ET Papoutsakis - Biotechnology Advances, 2023 - Elsevier
Extracellular vesicles (EVs) are cornerstones of intercellular communication with exciting
fundamental, clinical, and more broadly biotechnological applications. However, variability …
fundamental, clinical, and more broadly biotechnological applications. However, variability …
Gasdermin D deficiency in vascular smooth muscle cells ameliorates abdominal aortic aneurysm through reducing putrescine synthesis
J Gao, Y Chen, H Wang, X Li, K Li, Y Xu… - Advanced …, 2023 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …