The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
PARP and PARG inhibitors in cancer treatment
D Slade - Genes & development, 2020 - genesdev.cshlp.org
Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …
genomic instability through radiotherapy and chemotherapy has been a powerful but …
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
A Ray Chaudhuri, A Nussenzweig - Nature reviews Molecular cell …, 2017 - nature.com
Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …
which, if unrepaired, impairs genome integrity and leads to the development of various …
The comings and goings of PARP-1 in response to DNA damage
JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
[HTML][HTML] The importance of poly (ADP-ribose) polymerase as a sensor of unligated Okazaki fragments during DNA replication
H Hanzlikova, I Kalasova, AA Demin, LE Pennicott… - Molecular cell, 2018 - cell.com
Poly (ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance
Homologous recombination (HR) repair deficiency impairs the proper maintenance of
genomic stability, thus rendering cancer cells vulnerable to loss or inhibition of DNA repair …
genomic stability, thus rendering cancer cells vulnerable to loss or inhibition of DNA repair …
[HTML][HTML] The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
T Helleday - Molecular oncology, 2011 - Elsevier
Poly (ADP-ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the
BRCA1 or BRCA2 genes through the concept of synthetic lethality. It is suggested that PARP …
BRCA1 or BRCA2 genes through the concept of synthetic lethality. It is suggested that PARP …
PARP inhibition: PARP1 and beyond
Recent findings have thrust poly (ADP-ribose) polymerases (PARPs) into the limelight as
potential chemotherapeutic targets. To provide a framework for understanding these recent …
potential chemotherapeutic targets. To provide a framework for understanding these recent …
Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
Abstract Poly (ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA
breaks and attracting DNA repair proteins to the site of damage,,. Nevertheless, PARP1 …
breaks and attracting DNA repair proteins to the site of damage,,. Nevertheless, PARP1 …
Poly (ADP-ribose) polymerase inhibitors: recent advances and future development
CL Scott, EM Swisher, SH Kaufmann - Journal of Clinical Oncology, 2015 - ascopubs.org
Poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising activity in epithelial
ovarian cancers, especially relapsed platinum-sensitive high-grade serous disease …
ovarian cancers, especially relapsed platinum-sensitive high-grade serous disease …