Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

Peptide-based covalent probes can target shallow protein surfaces not typically addressable
using small molecules, yet there is a need for versatile approaches to convert native peptide …

Molecularly targeted radionuclide therapies (TRTs) struggle with balancing efficacy and
safety, as current strategies to increase tumor absorption often alter drug pharmacokinetics …

The covalent attachment of Ub (ubiquitin) to target proteins (ubiquitylation) represents one of
the most versatile PTMs (post-translational modifications) in eukaryotic cells. Substrate …

Viral infections have a major impact in human health. Ongoing viral transmission and
escalating selective pressure have the potential to favor the emergence of vaccine-and …

Recent years have seen a remarkable growth in the field of protein-based medical
treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low …

The ongoing COVID-19 pandemic has had great societal and health consequences. Despite
the availability of vaccines, infection rates remain high due to immune evasive Omicron …

Sulfur fluoride exchange (SuFEx) and phosphorus fluoride exchange (PFEx) click
chemistries are advancing research across multiple disciplines. By genetically incorporating …

Unnatural amino acids (UAAs) have gained significant attention in protein engineering and
drug development owing to their ability to introduce new chemical functionalities to proteins …