[HTML][HTML] The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease with the Compromised Status of Vitamin-Dependent Processes
V Bunik - Biology, 2023 - mdpi.com
Simple Summary The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease,
involving impaired vitamin metabolism and/or actions, are considered in light of the potential …
involving impaired vitamin metabolism and/or actions, are considered in light of the potential …
[HTML][HTML] Reverse and Forward Electron Flow-Induced H2O2 Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote …
α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase
complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been …
complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been …
[HTML][HTML] Delayed impact of 2-oxoadipate dehydrogenase inhibition on the rat brain metabolism is linked to protein glutarylation
AI Boyko, IS Karlina, LG Zavileyskiy, VA Aleshin… - Frontiers in …, 2022 - frontiersin.org
Background The DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-
oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly …
oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly …
Thiamine‐dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo
V Bunik, V Aleshin, I Nogues, T Kähne… - Journal of …, 2022 - Wiley Online Library
Vitamins B1 (thiamine) and B6 (pyridox (al/ine/amine)) are crucial for central nervous system
(CNS) function and neurogenesis due to the coenzyme action of their phosphorylated …
(CNS) function and neurogenesis due to the coenzyme action of their phosphorylated …
[HTML][HTML] Selective inhibition of 2-oxoglutarate and 2-oxoadipate dehydrogenases by the phosphonate analogs of their 2-oxo acid substrates
AV Artiukhov, AV Kazantsev, NV Lukashev… - Frontiers in …, 2021 - frontiersin.org
Phosphonate analogs of pyruvate and 2-oxoglutarate are established specific inhibitors of
cognate 2-oxo acid dehydrogenases. The present work develops application of this class of …
cognate 2-oxo acid dehydrogenases. The present work develops application of this class of …
[HTML][HTML] The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster.
SJ Marygold - microPublication Biology, 2024 - ncbi.nlm.nih.gov
The conserved family of alpha-ketoacid dehydrogenase complexes (AKDHCs) catalyze
essential reactions in central metabolism and their dysregulation is implicated in several …
essential reactions in central metabolism and their dysregulation is implicated in several …
Therapeutic Potential of Vitamins in Charcot-Marie-Tooth Disease with the Compromised Status of the Vitamin-Dependent Processes
V Bunik - 2023 - preprints.org
Understanding molecular mechanisms of neurological disorders is required for development
of personalized medicine. When the diagnosis considers not only the disease symptoms, but …
of personalized medicine. When the diagnosis considers not only the disease symptoms, but …