Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …

The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …

Chronic kidney disease (CKD) is a progressive systemic disease, which changes the
function and structure of the kidneys irreversibly over months or years. The final common …

Cisplatin is massively used to treat solid tumors. However, several severe adverse effects,
such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to …

As an important part of complementary and alternative medicine, traditional Chinese
medicine (TCM) has been applied to treat a host of diseases for centuries. Over the years …

Ferroptosis is an iron-and lipotoxicity-dependent regulated cell death that has been
implicated in various diseases, such as cancer, neurodegeneration and stroke. The …

Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …

The cost-effectiveness of presently used therapies is a problem in overall redox-based
management, which is posing a significant financial burden on communities across the …