Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

The resistance of microorganisms to antibiotics has been developing for more than 2 billion
years and is widely distributed among various representatives of the microbiological world …

Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of ap-
nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1, 3-propanediol …

Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …

Resistance to aminoglycoside antibiotics has had a profound impact on clinical practice.
Despite their powerful bactericidal activity, aminoglycosides were one of the first groups of …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Despite their inherent toxicity and the acquired bacterial resistance that continuously
threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable …

To address the growing problem of antibiotic resistance, a set of 12 hybrid compounds that
covalently link fluoroquinolone (ciprofloxacin) and aminoglycoside (kanamycin A) antibiotics …