The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Interferons (IFNs) are a family of multifunctional cytokines thatactivate transcription of
subsets of genes. The gene products inducedby IFNs are responsible for IFN antiviral …

The interferon (IFN)–inducible protein Z-DNA binding protein 1 [ZBP1; also known as DNA-
dependent activator of IFN regulatory factors (DAI) and DLM-1] was identified as a double …

Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We
report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and …

Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties,
but less is known about how they induce cell death. Here, we show that both type I (α/β) and …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

Necrosis has long been described as a consequence of physico-chemical stress and thus
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …

Tumor necrosis factor (TNF) is a pleiotropic molecule with a crucial role in cellular stress and
inflammation during infection, tissue damage, and cancer. TNF signaling can lead to three …

To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …

Human melanoma cells can be reprogrammed to terminally differentiate and irreversibly
lose proliferative capacity by appropriate pharmacological manipulation. Subtraction …