Importance Antiretroviral therapy (ART) is the cornerstone of prevention and management of
HIV infection. Objective To evaluate new data and treatments and incorporate this …

Modern ART has now achieved the goal of maintaining HIV RNA suppression with minimum
drug-related toxicities. Indeed, in high-income settings, the main health issues in adult …

Introduction: For two decades, triple combinations of antiretrovirals have been the standard
treatment for HIV infection. The challenges of such lifelong therapy include long-term side …

Antiretroviral (ARV) therapy, comprising a backbone of two nucleos (t) ide reverse
transcriptase inhibitors (NRTI s) plus another ARV, is the recognized standard of care (SOC) …

Background Reducing drug burden is a key challenge for achieving lifelong suppressive
HIV therapy. Dolutegravir, with a high potency, long half-life and high genetic barrier, offers …

As people live longer with HIV infection, there has been a resurgence of interest in
challenging the use of three-drug therapy, including two nucleoside reverse transcriptase …

Introduction As HIV has become a manageable chronic condition, a renewed and increased
interest in challenging traditional three-drug HIV therapies and moving toward two-drug …

During the last 30 years, antiretroviral treatment (ART) for human immunodeficiency virus
(HIV) infection has been continuously evolving. Since 1996, three-drug regimens (3DR) …

Time for antiretroviral therapy individualization Advances in the understanding of HIV
pathogenesis have led to a revolutionary improvement in the care of HIV-infected persons. It …

Abstract Purpose of Review Simplification of antiretroviral therapy is a strategy aiming to
reduce pill burden, drug interactions, and toxicity. This review focuses on the most recent …