Effects of caloric restriction diet on arterial hypertension and endothelial dysfunction
N Di Daniele, G Marrone, M Di Lauro, F Di Daniele… - Nutrients, 2021 - mdpi.com
The most common manifestation of cardiovascular (CV) diseases is the presence of arterial
hypertension (AH), which impacts on endothelial dysfunction. CV risk is associated with high …
hypertension (AH), which impacts on endothelial dysfunction. CV risk is associated with high …
SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation
X Liu, J Liu, W Xiao, Q Zeng, H Bo, Y Zhu, L Gong… - …, 2020 - Wiley Online Library
Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy
rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered …
rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered …
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia
T Chattopadhyay, B Maniyadath… - Proceedings of the …, 2020 - National Acad Sciences
Inefficient physiological transitions are known to cause metabolic disorders. Therefore,
investigating mechanisms that constitute molecular switches in a central metabolic organ …
investigating mechanisms that constitute molecular switches in a central metabolic organ …
O-GlcNAcylation of SIRT1 protects against cold stress-induced skeletal muscle damage via amelioration of mitochondrial homeostasis
Y Cao, M Zhang, Y Li, J Lu, W Zhou, X Li, H Shi… - International Journal of …, 2022 - mdpi.com
Cold stress disturbs cellular metabolic and energy homeostasis, which is one of the causes
of stress-induced illnesses. O-GlcNAcylation is a nutrient-sensing pathway involved in a …
of stress-induced illnesses. O-GlcNAcylation is a nutrient-sensing pathway involved in a …
Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease
M Noh, JY Sim, J Kim, JH Ahn, HY Min, JU Lee… - Journal of Hazardous …, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a group of illnesses associated with
unresolved inflammation in response to toxic environmental stimuli. Persistent exposure to …
unresolved inflammation in response to toxic environmental stimuli. Persistent exposure to …
[HTML][HTML] Histone deacetylase 6 inhibition counteracts the epithelial–mesenchymal transition of peritoneal mesothelial cells and prevents peritoneal fibrosis
L Xu, N Liu, H Gu, H Wang, Y Shi, X Ma, S Ma, J Ni… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The role of histone deacetylase 6 (HDAC6) in peritoneal fibrosis remains unknown. In this
study, we examined the effect of HDAC6 inhibition on the epithelial–mesenchymal transition …
study, we examined the effect of HDAC6 inhibition on the epithelial–mesenchymal transition …
NAD metabolites interfere with proliferation and functional properties of THP-1 cells
Over the past few years the NAD-related compounds nicotinamide (NAM), nicotinamide
riboside (NR) and 1-methylnicotinamide (MNA) have been established as important …
riboside (NR) and 1-methylnicotinamide (MNA) have been established as important …
The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD+ Level Is Lower than the Sirtuin-Saturating Concentrations
NC Yang, YH Cho, I Lee - International journal of molecular sciences, 2019 - mdpi.com
Calorie restriction can extend lifespan by increasing intracellular nicotinamide adenine
dinucleotide (NAD+), thereby upregulating the activity of sirtuins (Caenorhabditis elegans …
dinucleotide (NAD+), thereby upregulating the activity of sirtuins (Caenorhabditis elegans …
Over-expression of miR-34c leads to early-life visceral fat accumulation and insulin resistance
PH Jones, B Deng, J Winkler, AL Zirnheld, S Ehringer… - Scientific reports, 2019 - nature.com
Overweight children and adolescents are at high risk for adult and late life obesity. This
report investigates some underlying mechanisms contributing to obesity during early life in …
report investigates some underlying mechanisms contributing to obesity during early life in …
[HTML][HTML] SIRT1 coordinates transcriptional regulation of neural activity and modulates depression-like behaviors in the nucleus accumbens
Background Major depression and anxiety disorders are significant causes of disability and
socioeconomic burden. Despite the prevalence and considerable impact of these affective …
socioeconomic burden. Despite the prevalence and considerable impact of these affective …