Effect of reactive oxygen species on the endoplasmic reticulum and mitochondria during intracellular pathogen infection of mammalian cells

J Lee, CH Song - Antioxidants, 2021 - mdpi.com
Oxidative stress, particularly reactive oxygen species (ROS), are important for innate
immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune …

Glucose‐regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders

M Gonzalez‐Gronow, U Gopal, RC Austin… - IUBMB life, 2021 - Wiley Online Library
The 78 kDa glucose‐regulated protein (GRP78) is an endoplasmic reticulum (ER)‐resident
molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins …

Insights into the role of endoplasmic reticulum stress in infectious diseases

JA Choi, CH Song - Frontiers in immunology, 2020 - frontiersin.org
The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and
plays an important role in cellular functions. The unfolded protein response (UPR) is …

Herp regulates intracellular survival of Mycobacterium tuberculosis H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy

SH Son, J Lee, SN Cho, JA Choi, J Kim, TD Nguyen… - Mbio, 2023 - Am Soc Microbiol
Novel treatment strategies for tuberculosis (TB), such as host-directed therapeutics, may
offer therapeutic options for patients with drug-resistant TB. Endoplasmic reticulum (ER) …

M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria

YJ Lim, J Lee, JA Choi, SN Cho, SH Son, SJ Kwon… - Apoptosis, 2020 - Springer
Tumor suppressor p53 is not only affects immune responses but also contributes to
antibacterial activity. However, its bactericidal function during mycobacterial infection …

Liposome-encapsulated bacillus calmette–guérin cell wall skeleton enhances antitumor efficiency for bladder cancer in vitro and in vivo via induction of amp-activated …

YM Whang, DH Yoon, GY Hwang, H Yoon, SI Park… - Cancers, 2020 - mdpi.com
Simple Summary We engineered novel nanoparticles consisting of liposome-encapsulated
Bacillus Calmette–Guérin cell well skeleton (BCG-CWS) for intravesical instillation in …

Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages

J Lee, JA Choi, SN Cho, SH Son, CH Song - Cells, 2019 - mdpi.com
Apoptosis is an important host defense mechanism against mycobacterial infection.
However, the molecular mechanisms regulating apoptosis during mycobacterial infection …

Enhancement of the antimycobacterial activity of macrophages by ajoene

JA Choi, SN Cho, YJ Lim, J Lee, D Go… - Innate …, 2018 - journals.sagepub.com
Ajoene, a garlic-derived sulfur-containing compound, has broad-spectrum antimicrobial
activity. To assess the potential of ajoene for treating tuberculosis (TB), we determined …

TNF‐α‐mediated ER stress causes elimination of Mycobacterium fortuitum reservoirs by macrophage apoptosis

SM Oh, YJ Lim, JA Choi, J Lee, SN Cho… - The FASEB …, 2018 - Wiley Online Library
Mycobacterium fortuitum (MF), a rapidly growing nontuberculosis mycobacterium, is
recognized as an important human pathogen. We investigated whether the endoplasmic …

Discovery and overview of Par-4

S Ganguly, R Burikhanov, S Qiu… - Tumor Suppressor Par-4 …, 2022 - Springer
Abstract Prostate apoptosis response-4 (Par-4) is a tumor suppressor that was first identified
as an immediate early gene in a differential screen for genes induced during the process of …