Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms
S Kohtala - Pharmacological Reports, 2021 - Springer
Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …
medicine as an important anesthetic with many uses. More recently, ketamine has been …
Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …
Elevating the field for applying neuroimaging to individual patients in psychiatry
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in
decades past has been tempered by failed replications and a lack of definitive evidence to …
decades past has been tempered by failed replications and a lack of definitive evidence to …
The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity
The mechanism of action underlying ketamine's rapid antidepressant effects in patients with
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies
GC Medeiros, M Matheson, I Demo, MJ Reid… - The Lancet …, 2023 - thelancet.com
Ketamine is an effective antidepressant, but there is substantial variability in patient
response and the precise mechanism of action is unclear. Neuroimaging can provide …
response and the precise mechanism of action is unclear. Neuroimaging can provide …
[HTML][HTML] Neuroimaging-derived biomarkers of the antidepressant effects of ketamine
A Zavaliangos-Petropulu, NB Al-Sharif, B Taraku… - Biological psychiatry …, 2023 - Elsevier
Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive
range of treatment options, about a third of patients still struggle to respond to available …
range of treatment options, about a third of patients still struggle to respond to available …
Effect of Ketamine on Limbic GABA and Glutamate: A Human In Vivo Multivoxel Magnetic Resonance Spectroscopy Study
LR Silberbauer, B Spurny, P Handschuh… - Frontiers in …, 2020 - frontiersin.org
Introduction Converging evidence suggests that ketamine elicits antidepressant effects via
enhanced neuroplasticity precipitated by a surge of glutamate and modulation of GABA …
enhanced neuroplasticity precipitated by a surge of glutamate and modulation of GABA …
Evaluating global brain connectivity as an imaging marker for depression: influence of preprocessing strategies and placebo-controlled ketamine treatment
Major depressive disorder (MDD) is associated with altered global brain connectivity (GBC),
as assessed via resting-state functional magnetic resonance imaging (rsfMRI). Previous …
as assessed via resting-state functional magnetic resonance imaging (rsfMRI). Previous …