Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

The transcription factors Oct4, Sox2, Klf4, and c-Myc enable the reprogramming of somatic
cells into induced pluripotent cells. Reprogramming generates newly differentiated cells for …

There is an increasing interest in the study of the relation between alterations in systemic
lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral …

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease
marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor …

The complicated process of neuronal development is initiated early in life, with the genetic
mechanisms governing this process yet to be fully elucidated. Single-cell RNA sequencing …

Astrocytes play a crucial role in the onset and progression of amyotrophic lateral sclerosis
(ALS), a fatal disorder marked by the degeneration of motor neurons (MNs) in the central …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting
the upper and lower motor neurons, causing patients to lose control over voluntary …

Since the discovery of induced pluripotent stem cell (iPSC) technology, there have been
many attempts to create cellular models of inherited retinal diseases (IRDs) for investigation …

The primary neural circuit affected in Amyotrophic Lateral Sclerosis (ALS) patients is the
corticospinal motor circuit, originating in upper motor neurons (UMNs) in the cerebral motor …