Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
AM Miranda, ZM Lasiecka, Y Xu, J Neufeld… - Nature …, 2018 - nature.com
Defects in endolysosomal and autophagic functions are increasingly viewed as key
pathological features of neurodegenerative disorders. A master regulator of these functions …
pathological features of neurodegenerative disorders. A master regulator of these functions …
The biological functions and signaling mechanisms of the p75 neurotrophin receptor
BR Kraemer, SO Yoon, BD Carter - Neurotrophic factors, 2014 - Springer
The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …
including programmed cell death, axonal growth and degeneration, cell proliferation …
Astrocyte reactivity after brain injury—: the role of galectins 1 and 3
Astrocytes react to brain injury in a heterogeneous manner with only a subset resuming
proliferation and acquiring stem cell properties in vitro. In order to identify novel regulators of …
proliferation and acquiring stem cell properties in vitro. In order to identify novel regulators of …
Activated protein C in epilepsy pathophysiology
Epilepsy is one of the most common neurologic disorders that is characterized by recurrent
seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy's …
seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy's …
Bioinformatic analysis identifies key transcriptome signatures in temporal lobe epilepsy
QL Chen, L Xia, SP Zhong, Q Wang… - CNS neuroscience & …, 2020 - Wiley Online Library
Aims To identify transcriptome signatures underlying epileptogenesis in temporal lobe
epilepsy (TLE). Methods Robust rank aggregation analysis was used to integrate multiple …
epilepsy (TLE). Methods Robust rank aggregation analysis was used to integrate multiple …
A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress
The p75 neurotrophin receptor (p75 NTR) mediates the death of specific populations of
neurons during the development of the nervous system or after cellular injury. The receptor …
neurons during the development of the nervous system or after cellular injury. The receptor …
[HTML][HTML] FDG-PET and NeuN-GFAP immunohistochemistry of hippocampus at different phases of the pilocarpine model of temporal lobe epilepsy
L Zhang, Y Guo, H Hu, J Wang, Z Liu… - International journal of …, 2015 - ncbi.nlm.nih.gov
Purpose: Hippocampal glucose hypometabolism has been implicated in the pathogenesis of
temporal lobe epilepsy (TLE). However, the underlying pathophysiological basis for this …
temporal lobe epilepsy (TLE). However, the underlying pathophysiological basis for this …
Galectin-1 enhances TNFα-induced inflammatory responses in Sertoli cells through activation of MAPK signalling
Abstract Galectin-1 (Gal-1) is a pleiotropic lectin involved in the modulation of immune
responses. Using a model of rat experimental autoimmune orchitis (EAO), we investigated …
responses. Using a model of rat experimental autoimmune orchitis (EAO), we investigated …
Galectins and neuroinflammation
Galectins, β-galactoside-binding lectins, play multiple roles in the regulation of immune and
inflammatory responses. The major galectins expressed in the CNS are galectins 1, 3, 4, 8 …
inflammatory responses. The major galectins expressed in the CNS are galectins 1, 3, 4, 8 …
Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic …
B Riffault, N Kourdougli, C Dumon, N Ferrand… - Cerebral …, 2018 - academic.oup.com
The brain-derived neurotrophic factor (BDNF) is synthesized as a precursor, namely
proBDNF, which can be processed into mature BDNF (mBDNF). Evidences suggest that …
proBDNF, which can be processed into mature BDNF (mBDNF). Evidences suggest that …