ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment
M Pérez-Alea, K McGrail, S Sánchez-Redondo… - Oncogene, 2017 - nature.com
Despite the promising targeted and immune-based interventions in melanoma treatment,
long-lasting responses are limited. Melanoma cells present an aberrant redox state that …
long-lasting responses are limited. Melanoma cells present an aberrant redox state that …
Cathepsin B cleavable novel prodrug Ac‐Phe‐Lys‐PABC‐ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: an …
LH Shao, SP Liu, JX Hou, YH Zhang, CW Peng… - Cancer, 2012 - Wiley Online Library
BACKGROUND: Doxorubicin (Adriamycin) is effective in gastric cancer treatment, but with
severe dose‐dependent toxicities. A novel prodrug of doxorubicin (Ac‐Phe‐Lys‐PABC …
severe dose‐dependent toxicities. A novel prodrug of doxorubicin (Ac‐Phe‐Lys‐PABC …
Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model
YLB Klaver, T Hendriks, R Lomme… - Journal of British …, 2010 - academic.oup.com
Background The combination of cytoreductive surgery (CS) and hyperthermic intraperitoneal
chemotherapy (HIPEC) is the treatment of choice for selected patients with peritoneal …
chemotherapy (HIPEC) is the treatment of choice for selected patients with peritoneal …
Intraoperative versus early postoperative intraperitoneal chemotherapy after cytoreduction for colorectal peritoneal carcinomatosis: an experimental study
YLB Klaver, T Hendriks, RMLM Lomme… - Annals of surgical …, 2012 - Springer
Background Perioperative intraperitoneal chemotherapy is used as an adjunct to
cytoreductive surgery (CS) for peritoneal carcinomatosis (PC) in order to prolong survival …
cytoreductive surgery (CS) for peritoneal carcinomatosis (PC) in order to prolong survival …
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an …
L Tang, LJ Mei, XJ Yang, CQ Huang, YF Zhou… - Journal of translational …, 2011 - Springer
Background Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy
(HIPEC) has been considered as a promising treatment modality for gastric cancer with …
(HIPEC) has been considered as a promising treatment modality for gastric cancer with …
Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study
Q Wang, YJ Zhong, JP Yuan, LH Shao, J Zhang… - Journal of translational …, 2013 - Springer
Background This study was to investigate the effects and safety of cathepsin B-cleavable
doxorubicin (DOX)-prodrug (PDOX) for targeting therapy of metastatic human hepatocellular …
doxorubicin (DOX)-prodrug (PDOX) for targeting therapy of metastatic human hepatocellular …
Multimodal approach for treatment of peritoneal surface malignancies in a tumour-bearing rat model
W Raue, M Kilian, C Braumann, V Atanassow… - International journal of …, 2010 - Springer
Purpose Surgical cytoreduction of peritoneal surface malignancy of colorectal origin in
combination with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) has …
combination with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) has …
Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer
LJ Mei, XJ Yang, L Tang, AHAS Hassan, Y Yonemura… - BMC cancer, 2010 - Springer
Background Gastric cancer peritoneal carcinomatosis is a common clinical problem, but
there are no suitable large animal models to study this problem. This study was to establish …
there are no suitable large animal models to study this problem. This study was to establish …
Timing of adjuvant radioimmunotherapy after cytoreductive surgery in experimental peritoneal carcinomatosis of colorectal origin
F Aarts, MJ Koppe, T Hendriks, JEM van Eerd… - Annals of surgical …, 2007 - Springer
Background Treatment of patients with peritoneal carcinomatosis (PC) of colorectal cancer
(CRC) includes cytoreductive surgery (CS) in combination with (hyperthermic) …
(CRC) includes cytoreductive surgery (CS) in combination with (hyperthermic) …
Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar …
L Tang, R Duan, Y Zhong, RA Firestone, Y Hong, J Li… - Molecular cancer, 2014 - Springer
Background This work aimed to synthesize a cathepsin B (CTSB)-cleavable tumor-targeting
prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities on an …
prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities on an …