ContextMany US clinicians and laboratory personnel are unfamiliar with the diagnosis and
treatment of malaria. ObjectivesTo examine the evidence base for management of …

Clinical trials from the 1970s and 1980s have shown the efficacy, safety, and practicability of
the treatment of Plasmodium falciparum malaria with clindamycin. Two reviews from the …

Background Artemisinin-based combinations are recommended for treatment of
uncomplicated falciparum malaria, but are costly and in limited supply. Clindamycin plus …

Malaria, a parasite vector-borne disease, is one of the biggest health threats in tropical
regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid …

Therapeutic responses to clindamycin in combination with quinine were assessed in adult
Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total …

Malaria continues to be a major global health problem and seems to be increasing in some
parts of the world. By way of an introduction, relevant aspects of the disease, including …

The effects of adding rifampin to quinine were assessed in adults with uncomplicated
falciparum malaria. Patients were randomized to receive oral quinine either alone (n= 30) or …

The biowaiver approach permits evaluation of bioequivalence (BE) using a set of laboratory
tests, obviating the need for expensive and time-consuming pharmacokinetic BE studies …

We conducted a randomized, double-blind, placebo-controlled trial to compare a 3-day
quinine-clindamycin regimen (group QC) with a 7-day quinine regimen (group Q) for the …

Some antibacterial drugs have antimalarial activity that can be exploited for the prevention
or treatment of malaria. Monotherapy with tetracycline, doxycycline, clindamycin or …