Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

Objective To determine the prognostic value of persisting neuroinflammation in multiple
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …

To monitor innate immune responses in the CNS, the 18 kDa Translocator protein (TSPO) is
a frequently used target for PET imaging. The frequent assumption that increased TSPO …

Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …

Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …

The identification of progression in multiple sclerosis is typically retrospective. Given the
profound burden of progressive multiple sclerosis, and the recent development of effective …