Principles of actomyosin regulation in vivo

P Agarwal, R Zaidel-Bar - Trends in Cell Biology, 2019 - cell.com
The actomyosin cytoskeleton is responsible for most force-driven processes in cells and
tissues. How it assembles into the necessary structures at the right time and place is an …

Cytoplasm's got moves

S Shamipour, S Caballero-Mancebo, CP Heisenberg - Developmental Cell, 2021 - cell.com
Cytoplasm is a gel-like crowded environment composed of various macromolecules,
organelles, cytoskeletal networks, and cytosol. The structure of the cytoplasm is highly …

Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning

J Xie, J Najafi, R Le Borgne… - Proceedings of the …, 2022 - National Acad Sciences
Cells are filled with macromolecules and polymer networks that set scale-dependent viscous
and elastic properties to the cytoplasm. Although the role of these parameters in molecular …

Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes

K Harasimov, J Uraji, EU Mönnich, Z Holubcová… - Nature Cell …, 2023 - nature.com
Accurate chromosome segregation during meiosis is crucial for reproduction. Human and
porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly …

Polarity sorting drives remodeling of actin-myosin networks

V Wollrab, JM Belmonte, L Baldauf… - Journal of cell …, 2019 - journals.biologists.com
Cytoskeletal networks of actin filaments and myosin motors drive many dynamic cell
processes. A key characteristic of these networks is their contractility. Despite intense …

Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

W Yan, S Ansari, A Lamson, MA Glaser, R Blackwell… - Elife, 2022 - elifesciences.org
The cytoskeleton–a collection of polymeric filaments, molecular motors, and crosslinkers–is
a foundational example of active matter, and in the cell assembles into organelles that guide …

Functions of actin in mouse oocytes at a glance

J Uraji, K Scheffler, M Schuh - Journal of Cell Science, 2018 - journals.biologists.com
Gametes undergo a specialized and reductional cell division termed meiosis. Female
gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the …

Anillin propels myosin-independent constriction of actin rings

O Kučera, V Siahaan, D Janda, SH Dijkstra… - Nature …, 2021 - nature.com
Constriction of the cytokinetic ring, a circular structure of actin filaments, is an essential step
during cell division. Mechanical forces driving the constriction are attributed to myosin motor …

Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains

G Jafari, LA Khan, H Zhang, E Membreno, S Yan… - Science …, 2023 - science.org
In prevailing epithelial polarity models, membrane-and junction-based polarity cues such as
the partitioning-defective PARs specify the positions of apicobasal membrane domains …

Minimal coarse-grained models for molecular self-organisation in biology

AE Hafner, J Krausser, A Šarić - Current opinion in structural biology, 2019 - Elsevier
The molecular machinery of life is largely created via self-organisation of individual
molecules into functional assemblies. Minimal coarse-grained models, in which a whole …