Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Antibiotic discovery: history, methods and perspectives

GA Durand, D Raoult, G Dubourg - International journal of antimicrobial …, 2019 - Elsevier
Antimicrobial resistance is considered a major public-health issue. Policies recommended
by the World Health Organization (WHO) include research on new antibiotics. No new class …

Challenges of unculturable bacteria: environmental perspectives

A Bodor, N Bounedjoum, GE Vincze… - … Science and Bio …, 2020 - Springer
Environmental biotechnology offers several promising techniques for the rehabilitation of
polluted environments. The modern industrialized world presents novel challenges to the …

The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Thermostable cellulases: current status and perspectives

AK Patel, RR Singhania, SJ Sim, A Pandey - Bioresource technology, 2019 - Elsevier
It is envisaged that the utilization of lignocellulosic biomass for ethanol production for
transport sector, would make cellulases the most demanded industrial enzyme. The greatest …

Computational approaches to natural product discovery

MH Medema, MA Fischbach - Nature chemical biology, 2015 - nature.com
Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

Pesticide-tolerant microbial consortia: Potential candidates for remediation/clean-up of pesticide-contaminated agricultural soil

M Shahid, MS Khan, UB Singh - Environmental Research, 2023 - Elsevier
Reclamation of pesticide-polluted lands has long been a difficult endeavour. The use of
synthetic pesticides could not be restricted due to rising agricultural demand. Pesticide …

Minimum information about a biosynthetic gene cluster

MH Medema, R Kottmann, P Yilmaz… - Nature chemical …, 2015 - nature.com
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …

Strategies to diversify natural products for drug discovery

G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

LV Flórez, PHW Biedermann, T Engl… - Natural Product …, 2015 - pubs.rsc.org
Covering: through 2014 Many organisms team up with microbes for defense against
predators, parasites, parasitoids, or pathogens. Here we review the described protective …