Autoimmune diseases of the peripheral nervous system have so far been treated mainly with
exogenous high-dose intravenous immunoglobulins (IVIg), that act through several …

The discovery of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway was a major
advance in understanding eukaryotic signal transduction. The high frequency of PI 3-kinase …

Complex karyotype (CK) at chronic lymphocytic leukemia (CLL) diagnosis is a negative
biomarker of adverse outcome. Since the impact of CK and its subtypes, namely type-2 CK …

Simple Summary Cancer survivors can experience neurological complications after
exposure to anticancer therapy. Chemotherapy-induced peripheral neurotoxicity (CIPN) …

ABSTRACT Introduction: The phosphatidylinositol 3-kinase/protein kinase-B/mammalian
target of rapamycin (PI3K/AKT/mTOR) signaling pathway plays a central role in regulating …

Abstract RAS proteins (HRAS, KRAS, NRAS) participate in many physiological signal
transduction processes related to cell growth, division, and survival. The RAS proteins are …

Simple Summary This review focuses on the effects that a class of drugs, PI3Kδ inhibitors,
used for the treatment of patients with lymphoma can have not on the neoplastic cells but on …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

One of the main issues in the treatment of patients with chronic lymphocytic leukemia (CLL)
deals with the choice between continuous or fixed-duration therapy. Continuous ibrutinib …

Introduction Bruton's tyrosine kinase (BTK) is a multifaceted player of the immune system
which has been involved in the survival of hematological malignancies but also in the …