Virus-mediated cell-cell fusion

H Leroy, M Han, M Woottum, L Bracq… - International Journal of …, 2020 - mdpi.com
Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …

[HTML][HTML] Hepatitis C virus: Morphogenesis, infection and therapy

VA Morozov, S Lagaye - World journal of hepatology, 2018 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and
hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV …

Structure of the hepatitis C virus E1E2 glycoprotein complex

A Torrents de la Peña, K Sliepen, L Eshun-Wilson… - Science, 2022 - science.org
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and
hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The …

Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

MC Metcalf, BM Janus, R Yin, R Wang… - Nature …, 2023 - nature.com
Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of
chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV …

[HTML][HTML] CD81 and hepatitis C virus (HCV) infection

L Fénéant, S Levy, L Cocquerel - Viruses, 2014 - mdpi.com
Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million
individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and …

The mechanism of HCV entry into host cells

F Douam, D Lavillette, FL Cosset - Progress in molecular biology and …, 2015 - Elsevier
Hepatitis C virus (HCV) is an enveloped, positive strand RNA virus classified within the
Flaviviridae family and is a major cause of liver disease worldwide. HCV life cycle and …

Structures of the Hepaci-, Pegi-, and Pestiviruses envelope proteins suggest a novel membrane fusion mechanism

MR Oliver, K Toon, CB Lewis, S Devlin, RJ Gifford… - PLoS …, 2023 - journals.plos.org
Enveloped viruses encode specialised glycoproteins that mediate fusion of viral and host
membranes. Discovery and understanding of the molecular mechanisms of fusion have …

[PDF][PDF] Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry

F Douam, VL Dao Thi, G Maurin, J Fresquet… - …, 2014 - Wiley Online Library
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are important mediators for
productive cell entry. However, knowledge about their structure, intra‐or intermolecular …

Incorporation of hepatitis C virus E1 and E2 glycoproteins: the keystones on a peculiar virion

G Vieyres, J Dubuisson, T Pietschmann - Viruses, 2014 - mdpi.com
Hepatitis C virus (HCV) encodes two envelope glycoproteins, E1 and E2. Their structure and
mode of fusion remain unknown, and so does the virion architecture. The organization of the …

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

K El Omari, O Iourin, J Kadlec, G Sutton… - Nature …, 2014 - nature.com
Hepatitis C virus (HCV) infection remains a major health problem worldwide. HCV entry into
host cells and membrane fusion are achieved by two envelope glycoproteins, E1 and E2 …