The activation and regulation of β2 integrins in phagocytes and phagocytosis
Phagocytes, which include neutrophils, monocytes, macrophages, and dendritic cells,
protect the body by removing foreign particles, bacteria, and dead or dying cells. Phagocytic …
protect the body by removing foreign particles, bacteria, and dead or dying cells. Phagocytic …
The immunological synapse as a pharmacological target
F Finetti, CT Baldari - Pharmacological Research, 2018 - Elsevier
The development of T cell mediated immunity relies on the assembly of a highly specialized
interface between T cell and antigen presenting cell (APC), known as the immunological …
interface between T cell and antigen presenting cell (APC), known as the immunological …
Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem
AR Gingras, F Lagarrigue, MN Cuevas… - Journal of Cell …, 2019 - rupress.org
Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In
addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a …
addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a …
[HTML][HTML] Distinct integrin activation pathways for effector and regulatory T cell trafficking and function
Distinct integrin activation pathways for effector and regulatory T cell trafficking and function |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …
Using mechanistic models for the clinical interpretation of complex genomic variation
The sustained generation of genomic data in the last decade has increased the knowledge
on the causal mutations of a large number of diseases, especially for highly penetrant …
on the causal mutations of a large number of diseases, especially for highly penetrant …
Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation
RAP1-interacting adapter molecule (RIAM) mediates RAP1-induced integrin activation. The
RAS-association (RA) segment of the RA-PH module of RIAM interacts with GTP-bound …
RAS-association (RA) segment of the RA-PH module of RIAM interacts with GTP-bound …
The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning
of these cells in the environment. Integrins detect physical and chemical stimuli in the …
of these cells in the environment. Integrins detect physical and chemical stimuli in the …
Direct binding of Rap1 to Talin1 and to MRL proteins promotes integrin activation in CD4+ T cells
Agonist-induced Rap1 GTP loading results in integrin activation involved in T cell trafficking
and functions. MRL proteins Rap1-interacting adapter molecule (RIAM) and lamellipodin …
and functions. MRL proteins Rap1-interacting adapter molecule (RIAM) and lamellipodin …
The collagen matrix regulates the survival and function of pancreatic islets
Y Zhu, M Yang, W Xu, Y Zhang, L Pan, L Wang… - Endocrine, 2024 - Springer
The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of
cells, including pancreatic cells. Collagens are the most abundant components of the ECM …
cells, including pancreatic cells. Collagens are the most abundant components of the ECM …
Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs
Rap1 GTPase drives assembly of the Mig-10/RIAM/Lamellipodin (MRL protein)–integrin–
talin (MIT) complex that enables integrin-dependent lymphocyte functions. Here we used …
talin (MIT) complex that enables integrin-dependent lymphocyte functions. Here we used …