Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …

Vaginal microbiota composition affects many facets of reproductive health. Lactobacillus
iners-dominated microbial communities are associated with poorer outcomes, including …

Background and Purpose Posttranslational modifications of cysteine residues represent a
major aspect of redox biology, and their reliable detection is key in providing mechanistic …

Advanced phenotyping of cardiovascular diseases has evolved with the application of high-
resolution omics screening to populations enrolled in large-scale observational and clinical …

The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic
ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with …

Significance: Polysulfide species (ie, RS nR′, n> 2; and RS nH, n> 1) exist in many
organisms. The highly nucleophilic nature of hydropersulfides and hydropolysulfides …

Highlights•MMA has been implicated in mitochondrial oxidation stress, and the damage of
mitochondria-rich organs in children.•This study provides the first evidence that MMA is …

Background Riboflavin is a redox-active vitamin that plays a pivotal role in human energy
metabolism. Riboflavin may have beneficial health effects by increasing extracellular …

Background Serum sulfhydryl groups (R–SH, free thiols) reflect the systemic redox status in
health and disease, and may be amenable to therapeutic modulation. Since R–SH are …