Circadian Clocks, Daily Stress, and Neurodegenerative Disease
E Nyamugenda, C Rosensweig… - Annual Review of …, 2024 - annualreviews.org
Disrupted circadian or 24-h rhythms are among the most common early findings in a wide
range of neurodegenerative disorders. Once thought to be a mere consequence of the …
range of neurodegenerative disorders. Once thought to be a mere consequence of the …
Higher central circadian temperature amplitude is associated with greater metabolite rhythmicity in humans
Robust circadian rhythms are essential for optimal health. The central circadian clock
controls temperature rhythms, which are known to organize the timing of peripheral …
controls temperature rhythms, which are known to organize the timing of peripheral …
tauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data
As the circadian clock regulates fundamental biological processes, disrupted clocks are
often observed in patients and diseased tissues. Determining the circadian time of the …
often observed in patients and diseased tissues. Determining the circadian time of the …
On Weighted Trigonometric Regression for Suboptimal Designs in Circadian Biology Studies
M Gorczyca, J Sefas - arXiv preprint arXiv:2403.14452, 2024 - arxiv.org
Studies in circadian biology often use trigonometric regression to model phenomena over
time. Ideally, protocols in these studies would collect samples at evenly distributed and …
time. Ideally, protocols in these studies would collect samples at evenly distributed and …
A mixed effects cosinor modelling framework for circadian gene expression
MT Gorczyca - arXiv preprint arXiv:2405.01450, 2024 - arxiv.org
The cosinor model is frequently used to represent gene expression given the 24 hour day-
night cycle time at which a corresponding tissue sample is collected. However, the timing of …
night cycle time at which a corresponding tissue sample is collected. However, the timing of …
Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials
P Chan, Y Nagai, Q Wu, A Hovsepyan, S Mkhitaryan… - bioRxiv, 2024 - biorxiv.org
Background: It has been reported that circadian clock components, Brain and Muscle
ARNTLike 1 (BMAL1) and Circadian Locomotor Output Cycles Kaput (CLOCK), are uniquely …
ARNTLike 1 (BMAL1) and Circadian Locomotor Output Cycles Kaput (CLOCK), are uniquely …
[HTML][HTML] Variational inference of single cell time series
B Xu, R Braun - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Time course single–cell RNA sequencing (scRNA-seq) enables researchers to probe
genome–wide expression dynamics at the the single cell scale. However, when gene …
genome–wide expression dynamics at the the single cell scale. However, when gene …