Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options,
novel therapies are desperately needed. Recent studies have shown that GBM acquires …

Tumorigenesis is associated with elevated glucose and glutamine consumption, but how
cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal …

Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …

The identification of mechanisms to store glucose carbon in the form of glycogen rather than
fat in hepatocytes has important implications for the prevention of nonalcoholic fatty liver …

Background Fat deposition is an important economic consideration in pig production. The
amount of fat deposition in pigs seriously affects production efficiency, quality, and …

Abstract Progesterone Receptor Membrane Component 1 (PGRMC1) is located in many
different subcellular locations with many different attested and probably location-specific …

This is a preface by the guest editors of the special issue of Cancers featuring the biology of
progesterone (P4) receptor membrane component (PGRMC) proteins as it relates to …

The title usage of Latin Quo vadis 'where are you going'extends the question Unde venisti
from where 'did you come?'posed in the accompanying paper and extends consideration of …

Elevated lipogenesis is a common characteristic of cancer and metabolic diseases. Sterol
regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription …