[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies

A Catalano, D Iacopetta, J Ceramella, D Scumaci… - Molecules, 2022 - mdpi.com
Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

Phage therapy for antibiotic-resistant bacterial infections

GF Hatfull, RM Dedrick… - Annual Review of …, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …

Considerations for the use of phage therapy in clinical practice

GA Suh, TP Lodise, PD Tamma… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …

Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa

AJ Kunz Coyne, A El Ghali, D Holger, N Rebold… - Infectious diseases and …, 2022 - Springer
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa
isolates are frequent causes of serious nosocomial infections that may compromise the …

Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review

MS Mulani, EE Kamble, SN Kumkar… - Frontiers in …, 2019 - frontiersin.org
The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance
and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

Mechanisms and clinical importance of bacteriophage resistance

JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …

Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

B Van Nieuwenhuyse, D Van der Linden… - Nature …, 2022 - nature.com
Post-operative bacterial infections are a leading cause of mortality and morbidity after
ongoing liver transplantation. Bacteria causing these infections in the hospital setting can …