Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
Mechanisms of integral membrane protein insertion and folding
F Cymer, G Von Heijne, SH White - Journal of molecular biology, 2015 - Elsevier
The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to
understand because they underlie virtually all physiological processes in cells including key …
understand because they underlie virtually all physiological processes in cells including key …
Membrane protein folding and stability: physical principles
▪ Abstract Stably folded membrane proteins reside in a free energy minimum determined by
the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the …
the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the …
Membranes: a meeting point for lipids, proteins and therapies
PV Escribá, JM González‐Ros, FM Goñi… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• Membrane lipid composition• Membrane lipid structure• Membrane lipid
organization‐Why so many different lipids?‐Lipid mixing and demixing‐Lateral pressure …
organization‐Why so many different lipids?‐Lipid mixing and demixing‐Lateral pressure …
The versatile β-barrel membrane protein
WC Wimley - Current opinion in structural biology, 2003 - Elsevier
The β-barrel membrane protein is found in the outer membranes of bacteria, mitochondria
and chloroplasts. Approximately 2–3% of the genes in Gram-negative bacterial genomes …
and chloroplasts. Approximately 2–3% of the genes in Gram-negative bacterial genomes …
Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity
R Rathinakumar, WF Walkenhorst… - Journal of the American …, 2009 - ACS Publications
We recently described 10 peptides selected from a 16 384-member combinatorial library
based on their ability to permeabilize synthetic lipid vesicles in vitro. These peptides did not …
based on their ability to permeabilize synthetic lipid vesicles in vitro. These peptides did not …
[HTML][HTML] Thermodynamics of lipid–peptide interactions
J Seelig - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2004 - Elsevier
This review is focused on peptide molecules which exhibit a limited solubility in the aqueous
phase and bind to the lipid membrane from the aqueous medium. Surface adsorption …
phase and bind to the lipid membrane from the aqueous medium. Surface adsorption …
Folding of amphipathic α-helices on membranes: energetics of helix formation by melittin
AS Ladokhin, SH White - Journal of molecular biology, 1999 - Elsevier
Membranes have a potent ability to promote secondary structure formation in a wide range
of membrane-active peptides, believed to be due to a reduction through hydrogen bonding …
of membrane-active peptides, believed to be due to a reduction through hydrogen bonding …
Conserved and cooperative assembly of membrane-bound α-helical states of islet amyloid polypeptide
The conversion of soluble protein into β-sheet-rich amyloid fibers is the hallmark of a
number of serious diseases. Precursors for many of these systems (eg, Aβ from Alzheimer's …
number of serious diseases. Precursors for many of these systems (eg, Aβ from Alzheimer's …
[PDF][PDF] Energetics of Peptide–Bilayer Interactions
Although the problem of the folding of soluble proteins continues to resist solution, we at
least have a strong understanding of the general thermodynamic principles1, 2 and have …
least have a strong understanding of the general thermodynamic principles1, 2 and have …