Highlights•CCS distributions and shifts contain valuable information about
analytes.•Compound-dependent effects of gas, field and temperature explain calibration …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Highlights•IM-MS provides valuable tools for structural characterization of protein
complexes.•The spread of conformational states adopted by a protein can be captured by IM …

Collision cross section (CCS, Ω) values determined by ion mobility mass spectrometry (IM-
MS) provide the study of ion shape in the gas phase and use of these as further identification …

The mechanisms behind the Amyloid-β (Aβ) peptide neurotoxicity in Alzheimer's disease are
intensely studied and under debate. One suggested mechanism is that the peptides …

Membrane proteins interact with a myriad of lipid species in the biological membrane,
leading to a bewildering number of possible protein− lipid assemblies. Despite this inherent …

The last∼ 25 years has seen mass spectrometry (MS) emerge as an integral method in the
structural biology toolkit. In particular, MS has enabled the structural characterization of …

Native ion mobility-mass spectrometry (IM-MS) is a rapidly growing field for studying the
composition and structure of biomolecules and biomolecular complexes using gas-phase …

The mechanisms behind the Amyloid-β (Aβ) peptide neurotoxicity in Alzheimer's disease are
intensely studied and under debate. One suggested mechanism is that the peptides …

The use of charge-reducing reagents to generate lower-charge ions has gained popularity
in the field of native mass spectrometry (MS) and ion mobility mass spectrometry (IM-MS) …