Podocyte–actin dynamics in health and disease
Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …
that are involved in regulating the permselective properties of the glomerular filtration …
The importance of podocyte adhesion for a healthy glomerulus
Podocytes are specialized epithelial cells that cover the outer surfaces of glomerular
capillaries. Unique cell junctions, known as slit diaphragms, which feature nephrin and …
capillaries. Unique cell junctions, known as slit diaphragms, which feature nephrin and …
Identification of novel genetic risk factors for focal segmental glomerulosclerosis in children: results from the Chronic Kidney Disease in Children (CKiD) Cohort
A Durand, CA Winkler, N Vince, V Douillard… - American Journal of …, 2023 - Elsevier
Rationale & Objective Focal segmental glomerulosclerosis (FSGS) is a major cause of
pediatric nephrotic syndrome, and African Americans exhibit an increased risk for …
pediatric nephrotic syndrome, and African Americans exhibit an increased risk for …
ShcA adaptor protein promotes nephrin endocytosis and is upregulated in proteinuric nephropathies
Nephrin is a key structural component of the podocyte slit diaphragm, and proper expression
of nephrin on the cell surface is critical to ensure integrity of the blood filtration barrier …
of nephrin on the cell surface is critical to ensure integrity of the blood filtration barrier …
Advances in slit diaphragm signaling
Regulation of the connection between the slit diaphragm and the podocyte actin network
requires complex interplay between multiple signaling pathways. New discoveries …
requires complex interplay between multiple signaling pathways. New discoveries …
Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts
E Levy-Apter, E Finkelshtein, V Vemulapalli… - Journal of Biological …, 2014 - ASBMB
The non-receptor isoform of protein-tyrosine phosphatase ϵ (cyt-PTPe) supports adhesion
of bone-resorbing osteoclasts by activating Src downstream of integrins. Loss of cyt-PTPe …
of bone-resorbing osteoclasts by activating Src downstream of integrins. Loss of cyt-PTPe …
Recent advances in our understanding of insulin signalling to the podocyte
It is becoming increasingly clear that the insulin responses of a number of different cell types
within the kidney are important in the maintenance of normal renal function. This review …
within the kidney are important in the maintenance of normal renal function. This review …
[HTML][HTML] Grb2 regulates the proliferation of hematopoietic stem and progenitors cells
Abstract Although Hematopoietic Stem and Progenitor Cell (HSPC) proliferation, survival
and expansion have been shown to be supported by the cooperative action of different …
and expansion have been shown to be supported by the cooperative action of different …
The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo
Podocytes are specialized kidney cells that form the kidney filtration barrier through the
connection of their foot processes. Nephrin and Neph family transmembrane molecules at …
connection of their foot processes. Nephrin and Neph family transmembrane molecules at …
[HTML][HTML] ShcA expression in podocytes is dispensable for glomerular development but its upregulation is associated with kidney disease
Background: ShcA (SHC1) is a phosphotyrosine adaptor protein which plays broad
signaling roles within the cell. Systemic loss of ShcA during embryogenesis is lethal, while …
signaling roles within the cell. Systemic loss of ShcA during embryogenesis is lethal, while …