Heavy metals are essential for a wide range of biological processes, including the growth
and reproduction of cells, synthesis of biomolecules, many enzymatic reactions, and the …

The standard proteinogenic amino acids grant access to a myriad of chemistries that
harmonize to create life. Outside of these twenty canonical protein building blocks are …

Biocatalysis has become an important component of modern organic chemistry, presenting
an efficient and environmentally friendly approach to synthetic transformations. Advances in …

Genetic code expansion is a promising genetic engineering technology that incorporates
noncanonical amino acids into proteins alongside the natural set of 20 amino acids. This …

Highlights•Use of noncanonical amino acid (ncAAs) in therapeutics requires careful
evaluation.•NcAA-mediated strategies enable important routes to precisely defined …

Enzymes with well-defined three-dimensional structure have in-built information for
molecular organization in the near vicinity of the active sites—popularly known as enzyme …

We report the synthesis and characterization of a new series of permanently porous, three-
dimensional metal–organic frameworks (MOFs), M-HAF-2 (M= Fe, Ga, or In), constructed …

The chemical and physical properties of proteins are limited by the 20 canonical amino
acids. Genetic code manipulation allows for the incorporation of noncanonical amino acids …

Astonishing progress has been achieved in unlocking new‐to‐nature biocatalysis in the past
decades. The progress in protein engineering enabled research to efficiently incorporate …

The 22 genetically encoded amino acids (AAs) present in proteins (the 20 standard AAs
together with selenocysteine and pyrrolysine), are commonly referred as proteinogenic AAs …