Antimicrobial peptides: classification, design, application and research progress in multiple fields

Y Huan, Q Kong, H Mou, H Yi - Frontiers in microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and
they are an important part of the innate immune system of different organisms. AMPs have a …

Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds

M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms

AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …

Peptide design principles for antimicrobial applications

MDT Torres, S Sothiselvam, TK Lu… - Journal of molecular …, 2019 - Elsevier
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

Membrane active antimicrobial peptides: translating mechanistic insights to design

J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …

QSAR modeling: where have you been? Where are you going to?

A Cherkasov, EN Muratov, D Fourches… - Journal of medicinal …, 2014 - ACS Publications
Quantitative structure–activity relationship modeling is one of the major computational tools
employed in medicinal chemistry. However, throughout its entire history it has drawn both …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Antimicrobial peptides: interaction with model and biological membranes and synergism with chemical antibiotics

A Hollmann, M Martinez, P Maturana… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown
antimicrobial activity against a wide range of bacterial species, including multiresistant …

The expanding scope of antimicrobial peptide structures and their modes of action

LT Nguyen, EF Haney, HJ Vogel - Trends in biotechnology, 2011 - cell.com
Antimicrobial peptides (AMPs) are an integral part of the innate immune system that protect
a host from invading pathogenic bacteria. To help overcome the problem of antimicrobial …

Antimicrobial peptides and nanotechnology, recent advances and challenges

LS Biswaro, MG da Costa Sousa… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides are sequences of amino acids, which present activity against
microorganisms. These peptides were discovered over 70 years ago, and are abundant in …