The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

It has long been the dream of biologists to map gene expression at the single-cell level. With
such data one might track heterogeneous cell sub-populations, and infer regulatory …

There is a recognized and growing need for rapid and efficient cell assays, where the size of
microfluidic devices lend themselves to the manipulation of cellular populations down to the …

The unabated progress in next-generation sequencing technologies is fostering a wave of
new genomics, epigenomics, transcriptomics and proteomics technologies. These …

The handling of single cells is of great importance in applications such as cell line
development or single-cell analysis, eg, for cancer research or for emerging diagnostic …

Individual cell heterogeneity within a population can be critical to its peculiar function and
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …

Abstract Three‐dimensional (3D) printing, also called additive manufacturing (AM) or rapid
prototyping (RP), is a layer by layer manufacturing method and now has been widely used in …

Advances in whole-genome and whole-transcriptome amplification have permitted the
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …

Interest in the expanding catalog of uncultivated microorganisms, increasing recognition of
heterogeneity among seemingly similar cells, and technological advances in whole-genome …