Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

The necessity of disease models for bone/cartilage related disorders is well-recognized, but
the barrier between ex-vivo cell culture, animal models and the real human body has been …

The integration of tumor-on-a-chip technology with mini-tissues or organoids has emerged
as a powerful approach in cancer research and drug development. This review provides an …

Osteoporosis is a common bone and metabolic disease that is characterized by bone
density loss and microstructural degeneration. Human bone marrow-derived mesenchymal …

Long non-coding RNAs (lncRNA) are non-protein coding RNA molecules that are longer
than 200 nucleotides. The lncRNA molecule plays diverse roles in gene regulation …

Cell culture-based technologies are widely utilized in various domains such as drug
evaluation, toxicity assessment, vaccine and biopharmaceutical development, reproductive …

Cells are smart creatures that respond to every signal after isolation and in vitro culture.
Adipose-derived stem cells (ADSCs) gradually lose their characteristic spindle shape, multi …

Tissue Engineering (TE) represents a promising solution to fabricate engineered constructs
able to restore tissue damage after implantation. In the classic TE approach, biomaterials …

It has been proved that cell-imprinted substrates molded from template cells can be used for
the re-culture of that cell while preserving its normal behavior or to differentiate the cultured …

Defects in the cartilage caused by trauma, osteoarthritis, or other disorders invariably result
in severe joint pain and dysfunction. Without access to progenitor cells, blood, and nutrition …