Brain diseases, including tumors and neurodegenerative disorders, are among the most
serious health problems. Non-invasively high-resolution imaging methods are required to …

Cerebral perfusion, also referred to as cerebral blood flow (CBF), is one of the most
important parameters related to brain physiology and function. The technique of dynamic …

Surgical resection, one of the main clinical treatments of intracranial glioblastoma, bears the
potential risk of incomplete excision due to the inherent infiltrative character of the …

Objective To evaluate correlation between cumulative dose of gadobutrol and signal
intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted …

This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

The diagnostic capabilities of magnetic resonance imaging (MRI) have undergone
continuous and substantial evolution by virtue of hardware and software innovations and the …

Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is
very difficult to be completely excised by surgery due to its irregular shape. Here, we use an …

Surgical resection is a mainstay of brain tumor treatments. However, the completed excision
of malignant brain tumor is challenged by its infiltrative nature. Contrast enhanced magnetic …

Introduction Gadolinium-based contrast agents (GBCAs) have been used clinically since
1988 for contrast-enhanced magnetic resonance imaging (CE-MRI). Generally, GBCAs are …

Chronic cerebral hypoperfusion (CCH) induces cognitive impairment, but the compensative
mechanism of cerebral blood flow (CBF) is not fully understood. The present study mainly …