Amyloid fibrils are supramolecular protein assemblies with a fibrous morphology and cross-
β structure. The formation of amyloid fibrils typically follows a nucleation-dependent …

Amyloid fibrils are supramolecular protein assemblies represented by a cross-β structure
and fibrous morphology, whose structural architecture has been previously investigated …

Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases,
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …

Amyloid fibrils form through nucleation and growth. To clarify the mechanism involved, direct
observations of both processes are important. First, seed-dependent fibril growth of β2 …

Knowledge of the structure and dynamics of proteins and protein assemblies is critical both
for understanding the molecular basis of physiological and patho-physiological processes …

The formation of amyloid fibrils proceeds via a nucleation-dependent mechanism in which
nucleation phase is generally associated with a high free energy resulting in the rate-limiting …

The nucleation event of amyloid fibrils is one of the most crucial processes that dictate the
timing and rate of the pathology of diseases; however, information regarding how protein …

Amyloid fibrils are misfolded forms of proteins and are involved in various diseases. They
have been studied extensively with the aim to obtain a comprehensive understanding of …

The identification of the factors that enable normally folded proteins to remain in their soluble
and functional states is crucial for a comprehensive understanding of any biological system …

β2-Microglobulin (β2m) is the major structural component of amyloid fibrils deposited in a
condition known as dialysis-related amyloidosis. Despite numerous studies that have …