Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Understanding the pathogenesis of abdominal aortic aneurysms

H Kuivaniemi, EJ Ryer, JR Elmore… - Expert review of …, 2015 - Taylor & Francis
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

[HTML][HTML] Identification of key circRNAs/lncRNAs/miRNAs/mRNAs and pathways in preeclampsia using bioinformatics analysis

S Liu, X Xie, H Lei, B Zou, L Xie - Medical Science Monitor …, 2019 - ncbi.nlm.nih.gov
Identification of Key circRNAs/lncRNAs/miRNAs/mRNAs and Pathways in Preeclampsia Using
Bioinformatics Analysis - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Identification of crucial genes in abdominal aortic aneurysm by WGCNA

S Chen, D Yang, C Lei, Y Li, X Sun, M Chen, X Wu… - PeerJ, 2019 - peerj.com
Background Abdominal aortic aneurysm (AAA) is the full thickness dilation of the abdominal
aorta. However, few effective medical therapies are available. Thus, elucidating the …

[HTML][HTML] Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease

E Biros, G Gäbel, CS Moran, C Schreurs… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD) represent common
causes of morbidity and mortality in elderly populations which were previously believed to …

Mouse models for abdominal aortic aneurysm

J Golledge, SM Krishna, Y Wang - British Journal of …, 2022 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …

An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1+ vascular smooth muscle subtype involved in abdominal aortic …

L Yu, J Zhang, A Gao, M Zhang, Z Wang, F Yu… - … and Targeted Therapy, 2022 - nature.com
The developmental origin, anatomical location, and other factors contribute to aortic
heterogeneity in a physiological state. On this basis, vascular diseases occur at different …

Single-cell sequencing analysis and multiple machine learning methods identified G0S2 and HPSE as novel biomarkers for abdominal aortic aneurysm

T Xiong, XS Lv, GJ Wu, YX Guo, C Liu, FX Hou… - Frontiers In …, 2022 - frontiersin.org
Identifying biomarkers for abdominal aortic aneurysms (AAA) is key to understanding their
pathogenesis, developing novel targeted therapeutics, and possibly improving patients …