The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy

LS Tan, HH Lau, EM Abdelalim, CM Khoo… - Trends in Molecular …, 2024 - cell.com
Abstract Glucose-6-phosphatase catalytic subunit (G6PC) 1 and G6PC2 are crucial for
glucose metabolism, regulating processes like glycolysis, gluconeogenesis, and …

Pancreatic Cancer Risk in Prediabetes: A Systematic Meta-Analysis Approach

A Jain, PR Keesari, YS Pulakurthi, R Katamreddy… - Pancreas, 2024 - journals.lww.com
Objectives Pancreatic cancer and Prediabetes pose significant public health challenges.
Given the lack of strong evidence and inconsistencies, we performed a meta-analysis to …

The association of metabolic syndrome score trajectory patterns with risk of all cancer types

L Deng, T Liu, CA Liu, Q Zhang, MM Song, SQ Lin… - Cancer, 2024 - Wiley Online Library
Abstract Background Metabolic syndrome (MetS) elevates cancer risk. However, a single
MetS assessment does not fully reveal the long‐term association with cancer. Inflammation …

[HTML][HTML] Plasma-derived exosomal miRNAs as potentially novel biomarkers for latent autoimmune diabetes in adults

W Fan, H Pang, X Li, Z Xie, G Huang, Z Zhou - Diabetes Research and …, 2023 - Elsevier
Aim To characterize the exosomal miRNA profiles of latent autoimmune diabetes in adults
(LADA) and evaluate the biomarker potential of selected miRNAs to distinguish LADA from …

[HTML][HTML] The Impact of the Dietary Inflammatory Index, Fasting Blood Glucose, and Smoking Status on the Incidence and Survival of Pancreatic Cancer: A …

GH Lee, YH Kim, SM Woo, WJ Lee, SS Han, SJ Park… - Nutrients, 2024 - mdpi.com
Background: Pancreatic cancer (PC), a highly malignant cancer with a poor diagnosis, may
be influenced by diet-related inflammation. This study examined the association between …

[HTML][HTML] Fasting as an Adjuvant Therapy for Cancer: Mechanism of Action and Clinical Practice

Y Xie, H Ye, Z Liu, Z Liang, J Zhu, R Zhang, Y Li - Biomolecules, 2024 - mdpi.com
The fundamental biological characteristics of tumor cells are characterized by irregularities
in signaling and metabolic pathways, which are evident through increased glucose uptake …

Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer

S Li, Y Liu, X Sui, Y Zhuo, H Siqi, Z Sijia, Z Hui… - …, 2024 - Taylor & Francis
Aim: To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional
liposomes combined with gemcitabine. Methods: Liposomes were prepared through the thin …

[HTML][HTML] Biochemical and metabolic characterization of a G6PC2 inhibitor

EM Hawes, M Rahim, Z Haratipour, AR Orun… - Biochimie, 2024 - Elsevier
Three glucose-6-phosphatase catalytic subunits, that hydrolyze glucose-6-phosphate (G6P)
to glucose and inorganic phosphate, have been identified, designated G6PC1-3, but only …

[HTML][HTML] Diabetes mellitus and cancer

JW Hong - Cardiovascular Prevention and Pharmacotherapy, 2023 - synapse.koreamed.org
Diabetes mellitus and cancer are the most common life-threatening illnesses worldwide.
Previous epidemiological studies have suggested a strong association between diabetes …

[PDF][PDF] 上海市闵行区2 型糖尿病患者空腹血糖对恶性肿瘤发病率影响的回顾性队列研究

刘蒲, 李俊, 许慧琳 - 复旦学报(医学版), 2024 - jms.fudan.edu.cn
目的: 探讨2 型糖尿病(type 2 diabetes mellitus, T2DM) 患者恶性肿瘤的发病风险及空腹血糖对
其的影响. 方法: 采用回顾性队列研究的方法对2004—2020 年间上海市恶性肿瘤登记信息与 …