In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …

Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Tumor-associated macrophages (TAMs) are major components of the tumor
microenvironment (TME) which are closely associated with the tumor malignant progression …

Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Tumor‐associated macrophages (TAMs) are one of the most abundant cell types in
colorectal cancer (CRC) tumor microenvironment (TME). Recent studies observed …

Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …

Abstract Background Cancer stem cells (CSCs) play crucial role in tumor progression, drug
resistance and relapse in various cancers. CSC niche is comprised of various stromal cell …