Kir channel molecular physiology, pharmacology, and therapeutic implications
M Cui, L Cantwell, A Zorn, DE Logothetis - Pharmacology of Potassium …, 2021 - Springer
For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …
Relevance of KCNJ5 in Pathologies of Heart Disease
KM Meyer, N Malhotra, J Kwak… - International journal of …, 2023 - mdpi.com
Abnormalities in G-protein-gated inwardly rectifying potassium (GIRK) channels have been
implicated in diseased states of the cardiovascular system; however, the role of GIRK4 (Kir3 …
implicated in diseased states of the cardiovascular system; however, the role of GIRK4 (Kir3 …
Linked biaromatic compounds as cardioprotective agents
GV Mokrov - Archiv der Pharmazie, 2022 - Wiley Online Library
Cardiovascular diseases (CVDs) are widespread in the modern world, and their number is
constantly growing. For a long time, CVDs have been the leading cause of morbidity and …
constantly growing. For a long time, CVDs have been the leading cause of morbidity and …
Identification of Potential Modulators of a Pathogenic G Protein-Gated Inwardly Rectifying K+ Channel 4 Mutant: In Silico Investigation in the Context of Drug …
E Pitsillou, ANO Logothetis, JJ Liang, A El-Osta… - Molecules, 2023 - mdpi.com
Genetic abnormalities have been associated with primary aldosteronism, a major cause of
secondary hypertension. This includes mutations in the KCNJ5 gene, which encodes G …
secondary hypertension. This includes mutations in the KCNJ5 gene, which encodes G …
Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology
H He, C Tang, Z Cao, T Wang, M He, M Xiao, L Xiao… - Molecules, 2024 - mdpi.com
Bistorta vivipara is a medicinal plant with a long history, but there are few studies on the
effects of its medicinal components and endophytic bacteria on the accumulation of …
effects of its medicinal components and endophytic bacteria on the accumulation of …
An In Silico Investigation of the Pathogenic G151R G Protein-Gated Inwardly Rectifying K+ Channel 4 Variant to Identify Small Molecule Modulators
Primary aldosteronism is characterised by the excessive production of aldosterone, which is
a key regulator of salt metabolism, and is the most common cause of secondary …
a key regulator of salt metabolism, and is the most common cause of secondary …
Regulation of G Protein-Gated Inwardly Rectifying K+ Channel Activity
The βγ subunits of heterotrimeric G proteins (Gβγ) were shown in 1987 to directly activate
atrial K+ channels, underlying the acetylcholine-induced decrease in heart rate. In 2013 …
atrial K+ channels, underlying the acetylcholine-induced decrease in heart rate. In 2013 …
Therapeutic agent for drug-induced bradycardia and bradyarrhythmia
S Takashima, Y Asano, N Yamada, Y Kondo, Y Kawai - 2023 - Google Patents
Arrhythmias are conditions in which the heart rate or heart pulsation rhythm is irregular, and
have various electrocardiographic abnormalities. Arrhythmia due to abnormal heart rate can …
have various electrocardiographic abnormalities. Arrhythmia due to abnormal heart rate can …