The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection
H Shen, ZW Chen - Cellular & molecular immunology, 2018 - nature.com
Abstract Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-
related cytokines because they are either produced by Th17/Th22 cells or involved in their …
related cytokines because they are either produced by Th17/Th22 cells or involved in their …
Tuberculosis vaccine development: progress in clinical evaluation
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …
[HTML][HTML] Prevention of tuberculosis in macaques after intravenous BCG immunization
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide.
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …
[HTML][HTML] CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection
CD4 T cells are essential for immunity to tuberculosis because they produce cytokines,
including interferon-γ. Whether CD4 T cells act as" helper" cells to promote optimal CD8 T …
including interferon-γ. Whether CD4 T cells act as" helper" cells to promote optimal CD8 T …
[HTML][HTML] Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis
Recent data from mice and non-human primate models of tuberculosis suggested that
CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis …
CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis …
Recently activated CD4 T cells in tuberculosis express OX40 as a target for host-directed immunotherapy
AR Gress, CE Ronayne, JM Thiede… - Nature …, 2023 - nature.com
Abstract After Mycobacterium tuberculosis (Mtb) infection, many effector T cells traffic to the
lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77 …
lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77 …
CTLs: killers of intracellular bacteria
L Tian, W Zhou, X Wu, Z Hu, L Qiu, H Zhang… - Frontiers in Cellular …, 2022 - frontiersin.org
Many microbial pathogens have evolved a range of capabilities to evade host immune
defense mechanisms and to survive and multiply in host cells. The presence of host …
defense mechanisms and to survive and multiply in host cells. The presence of host …
IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection
S Yang, J Zeng, W Hao, R Sun, Y Tuo, L Tan… - International Journal of …, 2023 - mdpi.com
Interleukin-21 and its receptors (IL-21/IL-21R) aggravate chlamydial lung infection, while
macrophages (Mφ) are one of the main cells infected by chlamydia and the main source of …
macrophages (Mφ) are one of the main cells infected by chlamydia and the main source of …
Biomarkers of cell-mediated immunity to bovine tuberculosis
MV Palmer, TC Thacker, MM Rabideau… - Veterinary immunology …, 2020 - Elsevier
Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs),
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …
Striking a balance—cellular and molecular drivers of memory T cell development and responses to chronic stimulation
Effective adaptive immune responses are characterized by stages of development and
maturation of T and B cell populations that respond to disturbances in the host homeostasis …
maturation of T and B cell populations that respond to disturbances in the host homeostasis …