The importance of the complement system in clinical medicine has become evident during
the last decades and complement therapeutics has now reached the clinic. Thus, there is an …

Complement system aberrations have been identified as pathophysiological mechanisms in
a number of diseases and pathological conditions either directly or indirectly. Examples of …

The remarkable difference in success rates between clinical pancreas transplantation and
islet transplantation is poorly understood. Despite the same histocompatibility barrier and …

Complement activation with formation of biologically potent mediators like C5a and the
terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and …

The human pathogen Streptococcus pyogenes possesses a chromosomal region, the mga
regulon, that contains co-regulated genes important to the virulence of these bacteria. A …

Aims This study assessed the relationship between inflammatory mediators and indices of
infarct size and left-ventricular (LV) remodelling following successful primary percutaneous …

The effects of time, temperature, ethylene-diamine-tetra-acetic acid (EDTA), citrate and
heparin on in vitro complement activation were examined in enzyme immuno assays (EIA) …

Background. Porcine islets offer an attractive alternative to human islets in clinical islet
transplantation. The preferred method of islet transplantation is intraportal injection into the …

The terminal complement complex (TCC), consisting of C5b, C6, C7, C8, and C9, contains
neoantigens that are absent from the individual native components. Neoantigens are …

Complement activation after cardiopulmonary bypass is correlated with postoperative organ
dysfunction. Heparin coating of the entire blood-contact surface of the cardiopulmonary …