Porphyromonas gingivalis induction of TLR2 association with Vinculin enables PI3K activation and immune evasion

K Pandi, S Angabo, J Gnanasekaran, H Makkawi… - PLoS …, 2023 - journals.plos.org
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that thrives in the
inflamed environment of the gingival crevice, and is strongly associated with periodontal …

Crosstalk between integrin/FAK and Crk/Vps25 governs invasion of bovine mammary epithelial cells by S. agalactiae

Z Guo, Y Ma, Z Jia, L Wang, X Lu, Y Chen, Y Wang… - Iscience, 2023 - cell.com
Streptococcus agalactiae (S. agalactiae) is a contagious obligate parasite of the udder in
dairy cows. Here, we examined S. agalactiae-host interactions in bovine mammary epithelial …

Staphylococcus aureus keratinocyte invasion is mediated by integrin‐linked kinase and Rac1

S Sayedyahossein, SX Xu, A Rudkouskaya… - The FASEB …, 2015 - Wiley Online Library
Staphylococcus aureus is a major component of the skin microbiota and causes a large
number of serious infections. S. aureus first interacts with epidermal keratinocytes to breach …

Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling

ÉR Ferreira, E Horjales, A Bonfim-Melo, C Cortez… - Scientific reports, 2016 - nature.com
Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids
biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is …

Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF‐β‐regulated apoptosis signal in human gingival epithelial cells via …

T Yoshimoto, T Fujita, M Kajiya, K Ouhara… - Cellular …, 2016 - Wiley Online Library
Gingival junctional epithelial cell apoptosis caused by periodontopathic bacteria
exacerbates periodontitis. This pathological apoptosis is involved in the activation of …

PIP5KIγ90‐generated phosphatidylinositol‐4,5‐bisphosphate promotes the uptake of Staphylococcus aureus by host cells

Y Shi, A Berking, T Baade, KR Legate… - Molecular …, 2021 - Wiley Online Library
Staphylococcus aureus, a Gram‐positive pathogen, invades cells mainly in an integrin‐
dependent manner. As the activity or conformation of several integrin‐associated proteins …

Role of host cell integrins in the microsporidium Encephalitozoon intestinalis adherence and infection in vitro

CA Leonard, JR Hayman - FEMS Microbiology Letters, 2017 - academic.oup.com
Microsporidia are obligate intracellular, spore-forming, fungal-related pathogens that employ
a unique organelle, the polar tube, to transfer infectious spore contents into host cells to …

Particle size influences fibronectin internalization and degradation by fibroblasts

P Bozavikov, D Rajshankar, W Lee… - Experimental cell …, 2014 - Elsevier
The application of nanotechnology for drug targeting underlines the importance of
controlling the kinetics and cellular sites of delivery for optimal therapeutic outcomes. Here …

Giant cell formation by macrophages and lung epithelial cells: A unique method of cell-cell infection used by B. thailandensis involves tetraspanins

MIM AlGabri - 2019 - etheses.whiterose.ac.uk
Burkholderia thailandensis is widely used as a non-pathogenic model of Burkholderia
pseudomallei, the causative agent of melioidosis, a disease with a 90% mortality rate if …

Molecular and Functional Characterization of the Ser/Thr Phosphatase PPM1F

TM Grimm - 2021 - kops.uni-konstanz.de
Integrins are essential heterodimeric cell surface receptors that mediate extracellular matrix
adhesion and instruct animal cells about the chemical and mechanical properties of their …