Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet
of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of …

The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Cardiac myocytes, although large enough to make up most of the heart volume, are only a
minority of cells within the heart with fibroblasts and blood vessel components (endothelial …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …

Cardiac fibroblasts account for about 75% of all cardiac cells, but because of their small size
contribute only∼ 10–15% of total cardiac cell volume. They play a crucial role in cardiac …

Cardiac function is determined by the dynamic interaction of various cell types and the
extracellular matrix that composes the heart. This interaction varies with the stage of …

Recording intracellular (IC) bioelectrical signals is central to understanding the fundamental
behaviour of cells and cell networks in, for example, neural and cardiac systems,,,. The …

Structural remodeling of the myocardium associated with mechanical overload or cardiac
infarction is accompanied by the appearance of myofibroblasts. These fibroblast-like cells …