Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
The IL-17 family of cytokines in health and disease
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
The IL-23/IL-17 pathway in inflammatory skin diseases: from bench to bedside
T Liu, S Li, S Ying, S Tang, Y Ding, Y Li, J Qiao… - Frontiers in …, 2020 - frontiersin.org
Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by
the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells. IL-17A is …
the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells. IL-17A is …
IL-17 receptor–based signaling and implications for disease
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
IL-17 signaling: the yin and the yang
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …
An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression
Q Luo, Y Liu, K Shi, X Shen, Y Yang, X Liang, L Lu… - Immunity, 2023 - cell.com
Summary Anti-interleukin-17 (IL-17) therapy has been used in various autoimmune
diseases. However, the efficacy is unexpectedly limited in several IL-17-associated …
diseases. However, the efficacy is unexpectedly limited in several IL-17-associated …
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …
revision of the TH subset paradigm and substantial progress has been made in deciphering …
The role of interleukin-17 in tumor development and progression
IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …
Interleukin 17 family cytokines: signaling mechanisms, biological activities, and therapeutic implications
L Monin, SL Gaffen - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
The cytokines of the interleukin 17 (IL-17) family play a central role in the control of
infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory …
infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory …
Basic biology and role of interleukin‐17 in immunity and inflammation
C Zenobia, G Hajishengallis - Periodontology 2000, 2015 - Wiley Online Library
Interleukin‐17 (also known as interleukin‐17A) is a key cytokine that links T‐cell activation to
neutrophil mobilization and activation. As such, interleukin‐17 can mediate protective innate …
neutrophil mobilization and activation. As such, interleukin‐17 can mediate protective innate …