The development of lymphoid organs can be viewed as a continuum. At one end are
the'canonical'secondary lymphoid organs, including lymph nodes and spleen; at the other …

Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally
a problem of concern only to immunologists. With the discovery of l-selectin and its ligands …

Selective chemical reactions that are orthogonal to the diverse functionality of biological
systems have become important tools in the field of chemical biology. Two notable examples …

Abstract P-, E-and L-selectin constitute a family of cell adhesion receptors that mediate the
initial tethering and rolling of leukocytes on inflamed endothelium as a prelude to their firm …

Lymphocyte homing to secondary lymphoid tissue and lesions of chronic inflammation is
directed by multi-step interactions between the circulating cells and the specialized …

▪ Abstract The four essential building blocks of cells are proteins, nucleic acids, lipids, and
glycans. Also referred to as carbohydrates, glycans are composed of saccharides that are …

This report provides a perspective on metabolic glycoengineering methodology developed
over the past two decades that allows natural sialic acids to be replaced with chemical …

Interactions of selectins with cell-surface glycoconjugates mediate tethering and rolling
adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped …

The sulfonation (also known as sulfurylation) of biomolecules has long been known to take
place in a variety of organisms, from prokaryotes to multicellular species, and new biological …

Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now
been identified. Their essential role in generating binding sites for proteins interacting with …