Recent studies suggest that the majority of the human genome is transcribed, but only about
2% accounts for protein-coding exons. Long noncoding RNAs (lncRNAs) constitute a …

There is a growing body of evidence that links epigenetic modifications to type 2 diabetes.
Researchers have more recently investigated effects of commonly used medications …

Background Tamoxifen resistance remains a clinical challenge for hormone receptor-
positive breast cancer. Recently, dysregulations in autophagy have been suggested as a …

Abstract Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in
carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains …

Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo,
down-regulated at birth and then reappears in tumors. Its role in tumor initiation and …

DNA methylation is essential for mammalian development and physiology. Here we report
that the developmentally regulated H19 lncRNA binds to and inhibits S …

The H19 lncRNA has been implicated in development and growth control and is associated
with human genetic disorders and cancer. Acting as a molecular sponge, H19 inhibits …

Long non-coding RNAs (lncRNAs) play important roles in malignant neoplasia. Indeed,
many hallmarks of cancer define that the malignant phenotype of tumor cells are controlled …

Metformin, a US Food and Drug Administration-approved “star” drug used for diabetes
mellitus type 2, has become a topic of increasing interest to researchers due to its anti …