Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

SARS-CoV-2 induces a muted innate immune response compared to other respiratory
viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate …

MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S
rRNA gene. It is significantly expressed in response to stress or exercise and translocated to …

Mitochondrial DNA variants have previously associated with disease, but the underlying
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …

Background Mitochondria have a central role in cellular functions, aging, and in certain
diseases. They possess their own genome, a vestige of their bacterial ancestor. Over the …

For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …

The APOE4 allele is recognized as a significant genetic risk factor to Alzheimer's disease
(AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD …

Abstract Humanin (HN) is a 24-amino acid mitochondrial-derived polypeptide with cyto-
protective and anti-apoptotic effects that regulates the mitochondrial functions under stress …