Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

With few exceptions, proteins that constitute the proteome of mitochondria originate outside
of this organelle in precursor forms. Such protein precursors follow dedicated transportation …

Abstract Background The international SARS-CoV-2 pandemic has resulted in an urgent
need to identify new anti-viral drugs for treatment of COVID-19. The initial step to identifying …

The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide
range of cellular functions including adenosine triphosphate (ATP) production, lipid …

Metabolite fluctuations following nutrient metabolism or environmental stresses impact
various intracellular signaling networks and stress responses to maintain cellular and …

Translational control is important in all life, but it remains a challenge to accurately quantify.
When ribosomes translate messenger (m) RNA into proteins, they attach to the mRNA in …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with
limited effective therapeutic options readily available. We have previously demonstrated that …

Analogs of pyrrole alkaloid lamellarins exhibit anticancer activity by modulating multiple
cellular events. Lethal doses of several lamellarins were found to enhance autophagy flux in …

The heme-regulated kinase HRI is activated under heme/iron deficient conditions; however,
the underlying molecular mechanism is incompletely understood. Here, we show that iron …

During their complex life cycles, the Apicomplexan parasites Plasmodium falciparum and
Toxoplasma gondii employ several layers of regulation of their gene expression. One such …